TB-500 10mg
TB-500 10mg
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TB-500 10mg
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Each vial contains 10mg of lyophilized TB-500.
TB-500 is a synthetic peptide based on thymosin beta-4, a naturally occurring protein involved in cell structure and movement. Researchers use it to study cell migration, blood vessel formation, and tissue repair in cell and animal models.
When reconstituted with 2mL of bacteriostatic water, TB-500 yields a solution of 5mg/mL.
Before reconstitution, this product is stable at room temperature for short periods, such as during shipping, but refrigeration is recommended for longer-term storage. After reconstitution, it must be refrigerated. Keep away from direct light. This product is stored refrigerated until it ships.
Bacwater is free with any vial.
Canadian Based
01The PureChain Standard
Purity And Documentation
Your results are only as good as the compound you start with.
Every vial is labelled with its compound, vial size and molecular weight, and ships for laboratory research use only. Third-party testing details will be published here.
Supplied for in-vitro laboratory research only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
- Size
- 10mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- Molar mass
- 4963 Da
About This Compound
About TB-500
TB-500 is the research name for synthetic thymosin beta-4, a 43-residue, N-terminally acetylated peptide found in almost every nucleated cell and at especially high levels in platelets and white blood cells. Its best-characterised job is structural: it binds monomeric G-actin and holds it in reserve, which makes it one of the main regulators of how quickly a cell can rebuild its cytoskeleton. That role in cell structure and movement is why it is studied in cell migration, blood-vessel formation and tissue-repair models. The central LKKTETQ stretch is the actin-binding motif, and is also sold on its own under the same TB-500 name. PureChain Labs supplies TB-500 as a lyophilised powder for in-vitro laboratory research only.
Actin-Binding Peptide
Molecular Formula
Molecular Weight
Form
CAS Number
02Molecular Structure
The TB-500 molecule
An illustrative atomic representation generated from the compound record, alongside its verified molecular data. The structure figure is schematic – not a measured conformation.
- C
- H
- N
- O
- S/P
Molecular data from the public PubChem record (CID 16132341). View on PubChem
By The Numbers
TB-500 Research, By The Numbers
The figures that define TB-500 and how it is being studied. For laboratory research use only.
Amino Acids
N-terminally acetylated, ending ...Ala-Gly-Glu-Ser
Actin-Binding Motif
The LKKTETQ stretch that binds G-actin
Molecular Weight (g/mol)
C212H350N56O78S, PubChem CID 16132341
Research Areas
- Cell Migration
- Angiogenesis Models
- Tissue Repair Research
- Cytoskeleton Biology
How It Works
How TB-500 Works
The pathways TB-500 acts on, and what each one does. Described from preclinical and receptor-pharmacology literature.
Holding G-Actin In Reserve
Thymosin beta-4 binds monomeric (G-) actin one-to-one and keeps it from polymerising. The cell can then release that pool quickly when it needs to extend its cytoskeleton - the basic reason the peptide is tied to cell shape and movement.
- Binds monomeric G-actin 1:1
- Buffers the pool available for filament growth
- Central to cytoskeletal turnover
Movement And New Vessels
Because migration depends on rapid actin remodelling, thymosin beta-4 has been studied in cell and animal models of cell migration and angiogenesis, where it is reported to promote endothelial cell movement and tube formation.
- Studied in endothelial migration assays
- Angiogenesis reported in preclinical models
- Findings are specific to the model used
LKKTETQ And Ac-SDKP
Two short pieces of the molecule are studied on their own: the central LKKTETQ actin-binding motif (residues 17-23), and the N-terminal tetrapeptide Ac-SDKP, which is released by enzymatic cleavage and investigated separately in fibrosis research.
- LKKTETQ = residues 17-23
- Ac-SDKP = N-terminal tetrapeptide
- Each fragment is a distinct research compound
Uses And Applications
What TB-500 Is Researched For
The main areas TB-500 is studied in, and the qualitative magnitudes reported alongside them.
Cell Migration
The primary research use - in-vitro scratch and migration assays where actin-driven cell movement is the measured endpoint.
Angiogenesis Models
Applied in endothelial tube-formation and vessel-growth models in cell and animal studies.
Tissue Repair Research
Investigated in preclinical wound, dermal and cardiac repair models.
Cytoskeleton Biology
Used as a tool for studying G-actin sequestration and the regulation of filament assembly.
Compound Information
Full Specification
| Chemical Name | Thymosin Beta-4 (Timbetasin) |
|---|---|
| Sequence | Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-OH |
| Molecular Weight | 4963 Da |
| Molecular Formula | C212H350N56O78S |
| CAS Number | 77591-33-4 |
| Form | Lyophilized powder |
| Solubility | Water-soluble |
| Storage | Store lyophilized at −20 °C, protected from light and moisture |
| Vial Size | 10mg |
| PubChem CID | 16132341 |
FAQ
Common Questions About TB-500
What Is TB-500?
The research name for synthetic thymosin beta-4. This vial carries thymosin beta-4’s CAS number, 77591-33-4; PubChem lists it as timbetasin under CID 16132341, with the formula C212H350N56O78S and a molecular weight of 4963 g/mol.
Is TB-500 The Same As The 7-Residue Fragment?
The name is used for both. Some suppliers sell only the LKKTETQ fragment (residues 17-23) as TB-500. This listing follows the full 43-residue thymosin beta-4 identity printed on the vial - CAS 77591-33-4 and formula C212H350N56O78S.
What Does Thymosin Beta-4 Do In Cells?
Its best-characterised role is binding monomeric G-actin and holding it in reserve, which regulates how quickly the cytoskeleton can be rebuilt during cell movement.
What Is TB-500 Researched For?
Cell migration, angiogenesis, tissue-repair models and cytoskeleton biology, in cell and animal studies.
Is TB-500 Approved For Human Use?
No. Nothing supplied by PureChain Labs is approved for human use or sold for it. This material is supplied as a research chemical for in-vitro laboratory work only.
How Should Research-Grade TB-500 Be Stored?
As supplied it is a lyophilised powder; the vial directs storage in a cool, dry place in the lyophilised state, and refrigeration once reconstituted.
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Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA or Health Canada; this product is not intended to diagnose, treat, cure or prevent any disease.